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KMID : 0370220140580010007
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Yakhak Hoeji
2014 Volume.58 No. 1 p.7 ~ p.11
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Resistance Mechanism of Enterococcus faecalis to LCB01-0371, a New Oxazo
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Lee Hyun-Hee
Lee Su-Ro
Kwak Jin-Hwan
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Abstract
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To study the resistance mechanism of E. faecalis to LCB01-0371, several resistant mutants to LCB01-0371 or linezolid were isolated by step-wise selection. The frequency of spontaneous mutations resistant to LCB01-0371 was lower than that of linezolid in E. faecalis. The genetic variations in resistant mutants were analyzed by DNA sequencing of domain V of 23S rRNA in each mutant. The first-step mutant to LCB01-0371 had a G2576T point mutation in V domain of 23S rRNA. However, no resistant mutant to LCB01-0371 was isolated in second-step mutant selection.
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KEYWORD
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LCB01-0371, resistance mechanism, Oxazolidinone, E. faecalis
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